“GLP-1’s for Weight Loss. Do they actually work?”
Over the past few years, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have rapidly gained attention for their ability to help patients lose weight. Originally developed to treat type 2 diabetes, these medications mimic the naturally occurring hormone GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar, appetite, and satiety. As more clinical data emerged, researchers began to notice a significant side effect: sustained and often substantial weight loss. But the question remains—do GLP-1s really work for weight loss, and are they right for everyone?
The answer is yes, for many people, they do work—sometimes dramatically. Clinical trials have shown that patients using semaglutide or tirzepatide for weight loss can lose 10-20% of their body weight over a year or more, especially when combined with dietary changes and increased physical activity. These medications work by slowing gastric emptying and reducing appetite, helping patients feel full longer and eat less. Importantly, the weight loss tends to be gradual and more sustainable than crash diets or stimulant-based pills.
That said, GLP-1’s aren’t magic bullets. They are most effective when use as part of a comprehensive approach that includes healthy eating, movement, stress management, and sleep optimization. Some people experience side effects like nausea, constipation, or fatigue, especially when first starting. Others may plateau or regain weight if the medication is stopped too early. It’s also worth noting that not everyone qualifies for these medications; they are typically recommended for individuals with a a BMI ≥ 30, or ≥ 27 with a weight-related condition like pre-diabetes or hypertension.
In conclusion, GLP-1s can be powerful tools for weight loss—but they work best when part of a broader, sustainable lifestyle shift. They’re not a shortcut, but they can offer much-needed support for people who have struggled with their weight despite years of effort. As with any medication, it’s important to consult with a knowledgeable healthcare provider to see if GLP-1s are a safe and appropriate option for your individual needs.
At Saguaro Direct Care, we take a whole-person approach to your weight loss and begin with understanding your metabolic profile, formulating a sustainable exercise plan, and adjusting your diet to optimize results. We believe in staying on the lowest possible effective dose with the least side effects. Please reach out to us today to learn more.
Dr. Zane Ahmed, DO
Founder & Physician, Saguaro Direct Care
Board Certified in Internal Medicine
